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Kannt A, Rajagopal S, Kadnur SV, Suresh J, Bhamidipati RK, Swaminathan S, Hallur MS, Kristam R, Elvert R, Czech J, Pfenninger A, Rudolph C, Schreuder H, Chandrasekar DV, Mane VS, Birudukota S, Shaik S, Zope BR, Burri RR, Anand NN, Thakur MK, Singh M, Parveen R, Kandan S, Mullangi R, Yura T, Gosu R, Ruf S, Dhakshinamoorthy S (2018) A small molecule inhibitor of nicotinamide N -methyltransferase for the treatment of metabolic disorders

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Furthermore, NNMT knockdown can convert CAFs to normal fibroblasts, which suggests bidirectional interconversion (74)

Initial doses are lower to allow researchers to observe the models initial response